Synthesis and evaluation of new 5-aminolevulinic acid derivatives as prodrugs of protoporphyrin for photodynamic therapy
Author:
Affiliation:
1. Department of Pharmaceutical Science & Technology
2. College of Chemistry and Biology
3. Donghua University
4. Shanghai 201620
5. China
6. Shanghai Changhai Hospital
7. Shanghai Xianhui Pharmaceutical Co. Ltd.
8. Shanghai 200433
Abstract
Upon light activation, 13a can induce the production of PpIX in vivo which produces ROS and other reactive oxygen species to lead to the apoptosis of S180 cell tumors.
Funder
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Subject
Physical and Theoretical Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/PP/C7PP00203C
Reference31 articles.
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5. Porphyrin synthesis from ALA derivatives for photodynamic therapy. In vitro and in vivo studies
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