Photodegradation of prednisolone under UVB solar irradiation. Role of photogenerated ROS in the degradation mechanism

Author:

Cacciari R. Daniel12345ORCID,Reynoso Eugenia12345ORCID,Montejano Hernán A.12345ORCID,Biasutti M. Alicia12345ORCID

Affiliation:

1. Departamento de Química

2. Facultad de Ciencias Exactas

3. Físico-Químicas y Naturales

4. Universidad Nacional de Río Cuarto

5. X5804BYA Río Cuarto

Abstract

Schematic representation of the Photodegradation of prednisolone active substances with anti-inflammatory properties such as corticosteroids has increased considerably in the last few decades.

Funder

Consejo Nacional de Investigaciones Científicas y Técnicas

Publisher

Springer Science and Business Media LLC

Subject

Physical and Theoretical Chemistry

Reference51 articles.

1. H. H. Tonnesen , Photoreactivity of Drugs, in Solar Radiation and Human Health, ed. E. Bjertness, 2008, pp. 102–113

2. B. G. Katzung , Adrenocorticosteroids & Adrenocortical Antagonists, in Basic & Clinical Pharmacology, McGraw-Hill, 2007, ch. 39

3. Molecular mechanisms of anti-inflammatory action of glucocorticoids

4. Glucocorticosteroid inhibition of cytokine production: Relevance to antiallergic actions

5. WHO , Annex 1, 19th WHO Model List of Essential Medicines, 2015, WHO Medicines, website http://www.who.int/medicines/areas/quality_assurance

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