A novel NIR fluorescent probe for copper(<scp>ii</scp>) imaging in Parkinson's disease mouse brain-Reference-Cited by-同舟云学术

A novel NIR fluorescent probe for copper(ii) imaging in Parkinson's disease mouse brain

Published:2024 Issue:32 Volume:15 Page:13082-13089
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Chen Jianmei¹,Luo Rongqing¹,Li Shuang¹,Shao Jinping¹,Wang Ting¹,Xie Shumei¹,Xu Li¹²,You Qiuyun¹²³,Feng Shumin¹²^ORCID,Feng Guoqiang⁴^ORCID

Affiliation:

1. School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China

2. Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan 430065, China

3. Engineering Research Center of TCM Protection Technology and New Product Development for the Elderly Brain Health, Ministry of Education, Wuhan 430065, China

4. Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, PR China

Abstract

A NIR fluorescent probe (DDAO-Cu), capable of crossing the blood–brain barrier, revealed that Cu2+ was enriched in the cortex, hippocampus, and striatum during the advanced stages of Parkinson's disease, but suppressed in the substantia nigra region.

Funder

Natural Science Foundation of Hubei Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC03445G

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