Novel fleximer pyrazole-containing adenosine analogues: chemical, enzymatic and highly efficient biotechnological synthesis-Reference-Cited by-同舟云学术

Novel fleximer pyrazole-containing adenosine analogues: chemical, enzymatic and highly efficient biotechnological synthesis

Published:2021 Issue:34 Volume:19 Page:7379-7389
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Khandazhinskaya Anastasia¹^ORCID,Eletskaya Barbara²,Fateev Ilja²,Kharitonova Maria²,Konstantinova Irina²^ORCID,Barai Vladimir³,Azhayev Alex³,Hyvonen Mervi T.⁴,Keinanen Tuomo A.⁴,Kochetkov Sergey¹,Seley-Radtke Katherine⁵,Khomutov Alex¹^ORCID,Matyugina Elena¹^ORCID

Affiliation:

1. Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia

2. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russia

3. Metkinen Chemistry Oy, Microkatu 1, FI-70210 Kuopio, Finland

4. School of Pharmacy, Biocenter Kuopio, University of Eastern Finland, Kuopio Campus, P.O. Box 1627 Kuopio, FI-70211, Finland

5. Department of Chemistry & Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA

Abstract

An eco-friendly and scalable biotechnological method for fleximer nucleoside synthesis using E. coli cells overexpressing nucleoside phosphorylases.

Funder

Russian Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB01069G

Reference51 articles.

1. Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

2. The evolution of nucleoside analogue antivirals: A review for chemists and non-chemists. Part 1: Early structural modifications to the nucleoside scaffold

3. The evolution of antiviral nucleoside analogues: A review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold

4. “Fleximers”. Design and Synthesis of a New Class of Novel Shape-Modified Nucleosides1

5. Unexpected inhibition of S-adenosyl-l-homocysteine hydrolase by a guanosine nucleoside

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