Enhancement of the physicochemical properties of [Pt(dien)(nucleobase)]2+ for HIVNCp7 targeting-Reference-Cited by-同舟云学术

Enhancement of the physicochemical properties of [Pt(dien)(nucleobase)]2+ for HIVNCp7 targeting

Published:2017 Issue:2 Volume:8 Page:1269-1281
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Tsotsoros S. D.¹²³⁴,Lutz P. B.⁵⁶⁷⁸⁴,Daniel A. G.¹²³⁴,Peterson E. J.¹²³⁴⁹,de Paiva R. E. F.¹²³⁴^ORCID,Rivera E.¹²³⁴,Qu Y.¹²³⁴,Bayse C. A.¹⁰¹¹¹²⁴^ORCID,Farrell N. P.¹²³⁴⁹^ORCID

Affiliation:

1. Department of Chemistry

2. Virginia Commonwealth University

3. Richmond

4. USA

5. Department of Science

6. Technology and Mathematics

7. Regent University

8. Virginia 23464

9. Massey Cancer Center

10. Department of Chemistry and Biochemistry

11. Old Dominion University

12. Norfolk

Abstract

Building from tryptophan to the tryptophan-containing HIV Nucleocapsid 7 (HIVNCp7) protein we combine biophysical and computational studies to enhance stacking interactions of purines through platination. The incorporation into a weak Lewis acid electrophile, [Pt(dien)(Nucleobase)]²⁺ may lead to disruption of the HIVNCp7-RNA interaction.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

National Science Foundation

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C6SC03445D

Reference55 articles.

1. Exploration of the medical periodic table: towards new targets