Nickel-catalyzed hydrodefluorination/deuterodefluorination of CF<sub>3</sub>-alkenes with formic acid-Reference-Cited by-同舟云学术

Nickel-catalyzed hydrodefluorination/deuterodefluorination of CF₃-alkenes with formic acid

Published:2024 Issue:51 Volume:60 Page:6548-6551
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Yang Peng¹^ORCID,Yu Haiping¹,Zhai Runze¹,Zhou Jianrong Steve²^ORCID,Tang Bo¹^ORCID

Affiliation:

1. College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, P. R. China

2. State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China

Abstract

Reductive defluorination of β-CF3-cinnamates to gem-difluoroalkenes is catalyzed by a nickel hydride intermediate using formic acid. The reaction can produce both fluorine and deuterium in one operation when deuterated formic acid is used.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D4CC00918E

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