Antimicrobial photodynamic therapy fighting polymicrobial infections – a journey from in vitro to in vivo

Author:

Karner Lisa123,Drechsler Susanne123,Metzger Magdalena123,Hacobian Ara123,Schädl Barbara12345,Slezak Paul123,Grillari Johannes123ORCID,Dungel Peter123ORCID

Affiliation:

1. Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the AUVA Research Center

2. Vienna

3. Austria

4. University Clinic of Dentistry

5. Medical University of Vienna

Abstract

The batericidal effects of antimicrobial photodynamic therapy (aPDT), using methylene blue as a photosensitizer and pulsed red LED light for activation, were tested in various environments in vitro and in a wound model in mice infected with a fecal bacterial suspension.

Funder

Österreichische Forschungsförderungsgesellschaft

Publisher

Springer Science and Business Media LLC

Subject

Physical and Theoretical Chemistry

Reference47 articles.

1. WHO , Antimicrobial resistance: global report on surveillance 2014 . 2014 , World Health Organization , p. 257 , http://www.who.int

2. A Brief History of the Antibiotic Era: Lessons Learned and Challenges for the Future

3. Access to effective antimicrobials: a worldwide challenge

4. M. J. Renwick , V.Simpkin and E.Mossialos , in Targeting innovation in antibiotic drug discovery and development: The need for a One Health - One Europe - One World Framework , Copenhagen, Denmark , 2016

5. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis

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