Controllable construction of pharmaceutically significant scaffolds of 2,3-dihydroquinolin-4-one and benzoazepine-5-one <i>via</i> redox-neutral cascade hydride transfer/cyclization-Reference-Cited by-同舟云学术

Controllable construction of pharmaceutically significant scaffolds of 2,3-dihydroquinolin-4-one and benzoazepine-5-one via redox-neutral cascade hydride transfer/cyclization

Published:2022 Issue:19 Volume:9 Page:5205-5212
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Xie Ronghao¹,Chen Shixiao²,Wang Yufeng¹,Yin Xiangcong³,Li Shuai-Shuai¹^ORCID,Xu Lubin¹,Wang Liang¹^ORCID

Affiliation:

1. College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Changcheng Rd. #700, Qingdao 266109, P. R. China

2. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, No. 5 Yushan Road, Qingdao, 266003, P. R. China

3. Hematology Diagnosis Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P. R. China

Abstract

The scaffolds of 2,3-dihydroquinolin-4-one and benzoazepine-5-one were controllably constructed relying on cascade condensation/redox-neutral [1,6]/[1,7]-hydride transfer/cyclization from 2-aminoacetophenone and various aldehydes as well as isatins.

Funder

National Natural Science Foundation of China

Science and Technology Support Plan for Youth Innovation of Colleges and Universities of Shandong Province of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO01103D

Reference46 articles.

1. Asymmetric Synthesis of 2-Aryl-2,3-dihydro-4-quinolones by Rhodium-Catalyzed 1,4-Addition of Arylzinc Reagents in the Presence of Chlorotrimethylsilane

2. Synthesis of an Azide-Tagged Library of 2,3-Dihydro-4-quinolones