Photoprocesses of the tyrosine kinase inhibitor gefitinib: from femtoseconds to microseconds and from solution to cells-Reference-Cited by-同舟云学术

Photoprocesses of the tyrosine kinase inhibitor gefitinib: from femtoseconds to microseconds and from solution to cells

Published:2021 Issue:36 Volume:12 Page:12027-12035
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Tamarit Lorena¹²^ORCID,El Ouardi Meryem¹²,Andreu Inmaculada¹²^ORCID,Vayá Ignacio¹²^ORCID,Miranda Miguel A.¹²^ORCID

Affiliation:

1. Departamento de Química/Instituto de Tecnología Química UPV-CSIC, Universitat Politècnica de València, Camino de Vera s/n, 46022 València, Spain

2. Unidad Mixta de Investigación, Universitat Politècnica de València, Instituto de Investigación Sanitaria (IIS) La Fe, Hospital Universitari i Politècnic La Fe, Avenida de Fernando Abril Martorell 106, 46026, València, Spain

Abstract

Excitation of gefitinib leads to the formation of locally excited (LE) and/or charge transfer (ICT) states in the ps scale. In solution, both can evolve to the excited triplet state. In proteins, quenching of LE by electron donors leads to oxidation.

Funder

Instituto de Salud Carlos III

Conselleria d'Educació, Investigació, Cultura i Esport

Ministerio de Ciencia e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC03154F

Reference43 articles.

1. Protein Tyrosine Kinase Structure and Function