A look into amyloid formation by transthyretin: aggregation pathway and a novel kinetic model

Author:

Faria Tiago Q.1234ORCID,Almeida Zaida L.1234,Cruz Pedro F.5234ORCID,Jesus Catarina S. H.12345,Castanheira Pedro6784,Brito Rui M. M.12345

Affiliation:

1. Center for Neuroscience and Cell Biology

2. University of Coimbra

3. Coimbra

4. Portugal

5. Chemistry Department

6. Biocant – Biotechnology Innovation Center

7. Parque Tecnológico de Cantanhede

8. Cantanhede

Abstract

The kinetics of transthyretin aggregation from acid-unfolded monomers to amyloid fibrils was studied by several biophysical techniques and may be described as a two-step process with transient accumulation of oligomeric species.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

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