A look into amyloid formation by transthyretin: aggregation pathway and a novel kinetic model
Author:
Affiliation:
1. Center for Neuroscience and Cell Biology
2. University of Coimbra
3. Coimbra
4. Portugal
5. Chemistry Department
6. Biocant – Biotechnology Innovation Center
7. Parque Tecnológico de Cantanhede
8. Cantanhede
Abstract
The kinetics of transthyretin aggregation from acid-unfolded monomers to amyloid fibrils was studied by several biophysical techniques and may be described as a two-step process with transient accumulation of oligomeric species.
Funder
Fundação para a Ciência e a Tecnologia
Publisher
Royal Society of Chemistry (RSC)
Subject
Physical and Theoretical Chemistry,General Physics and Astronomy
Link
http://pubs.rsc.org/en/content/articlepdf/2015/CP/C4CP04549A
Reference42 articles.
1. Protein aggregation kinetics, mechanism, and curve-fitting: A review of the literature
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4. A Diversity of Assembly Mechanisms of a Generic Amyloid Fold
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