Non-classical β-carbonic anhydrase inhibitors-towards novel anti-mycobacterials

Author:

von Gnielinski Natascha123,Nienaber Lisa123,Mason Lyndel123,Ellis Samantha4567,Triccas James A.4567,Davis Rohan A.12389,Hofmann Andreas12389

Affiliation:

1. Eskitis Institute for Drug Discovery

2. Griffith University

3. Brisbane, Australia

4. Department of Infectious Diseases and Immunology

5. Sydney Medical School

6. The University of Sydney

7. , Australia

8. Queensland Tropical Health Alliance

9. Australia

Abstract

Mycobacterial carbonic anhydrases, such as the essential protein Rv3588c, are attractive drug targets since they constitute a different class of carbonic anhydrases than those found in humans.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Reference32 articles.

1. World Health Organisation , http://www.who.int/mediacentre/factsheets/fs104/en/index.html , 2013

2. F. D. C. Center , Morb. Mort. Wkly. Rep. , 2006 , 55 , 301

3. Tuberculosis

4. Immunology of Tuberculosis

5. Immune evasion by Mycobacterium tuberculosis: living with the enemy

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