Covalent modification of biological targets with natural products through Paal–Knorr pyrrole formation-Reference-Cited by-同舟云学术

Covalent modification of biological targets with natural products through Paal–Knorr pyrrole formation

Published:2017 Issue:9 Volume:34 Page:1051-1060
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Kornienko Alexander¹²³⁴^ORCID,La Clair James J.¹⁵⁴⁶⁷^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry

2. Texas State University

3. San Marcos

4. USA

5. University of California at San Diego

6. Xenobe Research Institute

7. San Diego

Abstract

This review examines the extent to which natural systems have adopted the Paal–Knorr reaction to engage nucleophilic amine groups within biological targets.

Funder

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/NP/C7NP00024C

Reference66 articles.

1. Eukaryotic protein glycosylation: a primer for histochemists and cell biologists

2. Natural Products and Their Biological Targets: Proteomic and Metabolomic Labeling Strategies

3. Protein-Reactive Natural Products

4. Promiscuity and Selectivity in Covalent Enzyme Inhibition: A Systematic Study of Electrophilic Fragments

5. Identification and Characterization of Reactive Metabolites in Natural Products-Driven Drug Discovery

Cited by 44 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Cascade Cyclization/Amination of para‐Quinone Methides with β‐Ketodinitriles: Synthesis of Polysubstituted Furans;Advanced Synthesis & Catalysis;2024-03-27

2. Microwave-assisted organic synthesis of pyrroles (Review);Pharmacia;2024-03-25

3. Sustainable Synthesis of Indole-Substituted Densely Functionalized Pyrrole;The Journal of Organic Chemistry;2024-01-10

4. Covalent Modification of Proteins by Osthole Reactive Metabolites using Proteomic Approaches;Current Drug Metabolism;2023-08

5. Synthesis and pyrolysis of various novel pyrrole ester fragrance precursors;Flavour and Fragrance Journal;2023-04-17