Engineering of lysine cyclodeaminase conformational dynamics for relieving substrate and product inhibitions in the biosynthesis of l-pipecolic acid-Reference-Cited by-同舟云学术

Engineering of lysine cyclodeaminase conformational dynamics for relieving substrate and product inhibitions in the biosynthesis of l-pipecolic acid

Published:2019 Issue:2 Volume:9 Page:398-405
ISSN:2044-4753
Container-title:Catalysis Science & Technology
language:en
Short-container-title:Catal. Sci. Technol.

Author:

Ying Hanxiao¹²³⁴,Wang Jing¹²³⁴,Shi Ting⁵⁶⁷⁴,Zhao Yilei⁵⁶⁷⁴,Ouyang Pingkai¹²³⁴,Chen Kequan¹²³⁴^ORCID

Affiliation:

1. College of Biotechnology and Pharmaceutical Engineering

2. Nanjing Tech University

3. Nanjing

4. China

5. School of Life Sciences and Biotechnology

6. Shanghai Jiaotong University

7. Shanghai

Abstract

Efficient biocatalytic process construction by relieving substrate and product inhibitions via identification and engineering of enzyme conformational dynamics.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CY/C8CY02301H

Reference62 articles.

1. Tailoring new enzyme functions by rational redesign

2. De novo design of biocatalysts

3. Semi-rational approaches to engineering enzyme activity: combining the benefits of directed evolution and rational design

4. Engineering of the Conformational Dynamics of an Enzyme for Relieving the Product Inhibition

5. Effect of Overall Feedback Inhibition in Unbranched Biosynthetic Pathways

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