Rubrolide analogues and their derived lactams as potential anticancer agents-Reference-Cited by-同舟云学术

Rubrolide analogues and their derived lactams as potential anticancer agents

Published:2016 Issue:2 Volume:7 Page:345-352
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Pereira U. A.¹²³⁴,Moreira T. A.¹²³⁴,Barbosa L. C. A.¹²³⁴¹,Maltha C. R. A.¹²³⁴,Bomfim I. S.⁵⁶⁷⁴,Maranhão S. S.⁵⁶⁷⁴,Moraes M. O.⁵⁶⁷⁴,Pessoa C.⁵⁶⁷⁴⁸,Barros-Nepomuceno F. W. A.⁹¹⁰¹¹⁴

Affiliation:

1. Department of Chemistry

2. Federal University of Viçosa

3. Viçosa

4. Brazil

5. Center for Research and Drug Development

6. Federal University of Ceará

7. Fortaleza

8. Oswaldo Cruz Foundation

9. Institute of Health Sciences

10. University of International Integration of the Afro-Brazilian Lusophony

11. Acarape

Abstract

Analogues of rubrolides were synthesized and shown to be cytotoxic to several cancer cell lines and not toxic to L929 normal cells. The cytotoxicity involved the induction of cell death by apoptosis.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado de Minas Gerais

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MD/C5MD00459D

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