Orthoester functionalizedN-guanidino derivatives of 1,5-dideoxy-1,5-imino-d-xylitol as pH-responsive inhibitors of β-glucocerebrosidase-Reference-Cited by-同舟云学术

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Orthoester functionalizedN-guanidino derivatives of 1,5-dideoxy-1,5-imino-d-xylitol as pH-responsive inhibitors of β-glucocerebrosidase

Published:2017 Issue:11 Volume:8 Page:2050-2054
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Sevšek Alen¹²³⁴,Sastre Toraño Javier¹²³⁴,Quarles van Ufford Linda¹²³⁴,Moret Ed E.¹²³⁴,Pieters Roland J.¹²³⁴^ORCID,Martin Nathaniel I.¹²³⁴^ORCID

Affiliation:

1. Utrecht Institute for Pharmaceutical Sciences

2. Utrecht University

3. 3584 CG Utrecht

4. The Netherlands

Abstract

Alkylated guanidinium iminosugar derivatives bearing a pH sensitive orthoester moiety are potent and selective β-glucosidase inhibitors.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C7MD00480J

Reference53 articles.

1. Sphingolipid lysosomal storage disorders

2. Pharmacological Chaperones: Design and Development of New Therapeutic Strategies for the Treatment of Conformational Diseases

3. Pharmacological Chaperone Therapy: Preclinical Development, Clinical Translation, and Prospects for the Treatment of Lysosomal Storage Disorders

4. Strain-specific antiviral activity of iminosugars against human influenza A viruses

5. Glycosphingolipids-Nature, Function, and Pharmacological Modulation

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