An organophotocatalytic late-stage N–CH3 oxidation of trialkylamines to N-formamides with O2 in continuous flow-Reference-Cited by-同舟云学术

An organophotocatalytic late-stage N–CH3 oxidation of trialkylamines to N-formamides with O2 in continuous flow

Published:2022 Issue: Volume: Page:
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Mandigma Mark John P.¹^ORCID,Žurauskas Jonas¹,MacGregor Callum I.²^ORCID,Edwards Lee J.²^ORCID,Shahin Ahmed¹³^ORCID,d'Heureuse Ludwig¹,Yip Philip⁴,Birch David J. S.⁴^ORCID,Gruber Thomas¹,Heilmann Jörg¹,John Matthew P.²,Barham Joshua P.¹^ORCID

Affiliation:

1. Fakultät für Chemie und Pharmazie, Universität Regensburg, 93040 Regensburg, Germany

2. GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, UK

3. Chemistry Department, Faculty of Science, Benha University, 13518 Benha, Egypt

4. Department of Physics, SUPA, University of Strathclyde, 107 Rottenrow East, Glasgow, G4 0NG, UK

Abstract

An N–CH3-selective trialkylamine oxidation to N-formamides is reported in continuous flow using gaseous O2. A novel, enhanced-solubility dicyanoanthracene organophotocatalyst switched the photochemical mechanism from electron to energy transfer.

Funder

Alexander von Humboldt-Stiftung

GlaxoSmithKline

Scottish Funding Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D1SC05840A

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1. An overview of late-stage functionalization in today’s drug discovery