Reversibly-bonded microfluidic devices for stable cell culture and rapid, gentle cell extraction

Author:

Feng Xiaohan1ORCID,Wu Zehaoyu2ORCID,Cheng Lily Kwan Wai2,Xiang Yang3,Sugimura Ryohichi3,Lin Xuyan24ORCID,Wu Angela Ruohao125ORCID

Affiliation:

1. Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR

2. Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR

3. Li Ka Shing Faculty of Medicine, School of Biomedical Sciences, University of Hong Kong, Hong Kong SAR, China

4. Center for Engineering Material and Reliability, Guangzhou HKUST Fok Ying Tung Research Institute, Guangzhou, China

5. State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong SAR

Abstract

This reversible bonding approach allows for rapid and gentle live cell extraction after long-term on-chip culturing, facilitating downstream manipulation and characterization, and opening new avenues for various applications.

Funder

Research Grants Council, University Grants Committee

Innovation and Technology Commission - Hong Kong

Publisher

Royal Society of Chemistry (RSC)

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