EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block DSS-induced colitis in mice by a reinforced colonic mucus barrier-Reference-Cited by-同舟云学术

EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block DSS-induced colitis in mice by a reinforced colonic mucus barrier

Published:2022 Issue:8 Volume:13 Page:4399-4420
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Fang Jian¹²,Zhang ZhuangWei¹^ORCID,Cheng Yinyin¹,Yang Haitao³,Zhang Hui¹,Xue Zhe¹,Lu Songtao¹,Dong Yichen¹,Song Chunyan¹,Zhang Xiaohong¹⁴^ORCID,Zhou Yuping⁴⁵^ORCID

Affiliation:

1. Department of Preventive Medicine, Zhejiang Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, 818 Fenghua Road, Ningbo, Zhejiang, 315211, People's Republic of China

2. College of Medicine, Shaoxing University, 508 Huancheng Road, Shaoxing, Zhejiang Province, 312000, People's Republic of China

3. Mingzhou Hospital of Zhejiang University Department of Pathology, Mingzhou Hospital of Zhejiang University, Ningbo, 315040 Zhejiang, People's Republic of China

4. Department of Gastroenterology and hepatology, The Affiliated Hospital of Medical School, Ningbo University, 247 Renmin Road, Ningbo, Zhejiang, 315020, People's Republic of China

5. Institute of Digestive Disease of Ningbo University, Ningbo, 315020, People's Republic of China

Abstract

The intestinal mucus barrier nourishes and tames the gut microbiota using its glycans during homeostasis. EPA fortifies the intestinal mucus barrier, this was mediated by coordination of the interaction between the host and gut microbiota.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Zhejiang Key Laboratory of Pathophysiology

Zhejiang Province Public Welfare Technology Application Research Project

Medical Science and Technology Project of Zhejiang Province

K. C. Wong Magna Fund in Ningbo University

Shaoxing University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science