A hairpin-contained i-motif guided DNA nanoantenna for sensitive and specific sensing of tumor extracellular pH gradients

Author:

Ma Wenjie12,Wu Yuchen2,Li Jinyan1,Yang Mei1,Zhang He1,Liu Chang1,He Xiaoxiao2ORCID

Affiliation:

1. Hunan Provincial Key Laboratory of Environmental Catalysis and Waste Recycling, College of Materials and Chemical Engineering, Hunan Institute of Engineering, Xiangtan 411104, China

2. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecule Engineering of Hunan Province, Changsha 410082, China

Abstract

Inspired by the stimuli-responsive behavior of antennas receiving external signals, we designed a pH-stimulated and aptamer-anchored Y-shaped DNA nanoantenna for sensitive and specific sensing of tumor extracellular pH gradients.

Funder

Natural Science Foundation of Hunan Province

Education Department of Hunan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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