A COX2-targeting cancer-specific fluorescent probe for hydrogen sulfide detection in living cells, <i>Caenorhabditis elegans</i>, and zebrafish-Reference-Cited by-同舟云学术

A COX2-targeting cancer-specific fluorescent probe for hydrogen sulfide detection in living cells, Caenorhabditis elegans, and zebrafish

Published:2024 Issue:5 Volume:149 Page:1489-1495
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Yuan Fengying¹²,Zhao Qiao³,Zeng Yanyan¹,Liao Xu Fang³,Li Jiali¹,Liu Bo³,Kou Jun Feng³^ORCID,Zhong Xiaolin⁴,Wu Xiang Hua³^ORCID,Zhang Jun Feng³,Ren Wen Xiu¹

Affiliation:

1. Department of Radiology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China

2. Functional and Molecular Imaging Key Laboratory of Sichuan Province, Chengdu 610000, China

3. College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China

4. Department of Gastroenterology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China

Abstract

A novel H2S-activated cancer-specific fluorescent probe COX2-H2S was rationally developed, with naphthalimide as the fluorophore and indomethacin as the targeting unit, for the imaging determination of H2S in living cells, C. elegans, and zebrafish.

Funder

National Natural Science Foundation of China

Yunnan Provincial Department of Education

Natural Science Foundation of Yunnan Province

Ministry of Education of the People's Republic of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/AN/D3AN01847D

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