Naphthylisoindolinone alkaloids: the first ring-contracted naphthylisoquinolines, from the tropical liana <i>Ancistrocladus abbreviatus</i>, with cytotoxic activity-Reference-Cited by-同舟云学术

Naphthylisoindolinone alkaloids: the first ring-contracted naphthylisoquinolines, from the tropical liana Ancistrocladus abbreviatus, with cytotoxic activity

Published:2022 Issue:45 Volume:12 Page:28916-28928
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Fayez Shaimaa¹²,Bruhn Torsten²^ORCID,Feineis Doris¹,Assi Laurent Aké³,Kushwaha Prem Prakash⁴⁵,Kumar Shashank⁴,Bringmann Gerhard¹^ORCID

Affiliation:

1. Institute of Organic Chemistry, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany

2. Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Organization of African Unity Street 1, 11566 Cairo, Egypt

3. Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, D-10589 Berlin, Germany

4. Centre National de Floristique, Université d'Abidjan, Conservatoire et Jardin Botanique, Abidjan 08, Ivory Coast

5. Molecular Signaling & Drug Discovery Laboratory, Department of Biochemistry, Central University of Punjab, Bathinda-151401, Punjab, India

Abstract

Ancistrobrevoline A is the first example of a new subtype of naphthylisoquinoline alkaloids. Here the isoquinoline part is ring-contracted to give a chiral isoindolinone heterocycle. It reduces mammosphere formation in MCF-7 breast cancer cells.

Funder

Deutscher Akademischer Austausch Dienst Kairo

Deutsche Forschungsgemeinschaft

Deutscher Akademischer Austauschdienst

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA05758A

Reference65 articles.

1. A Synoptic Revision of Ancistrocladus (Ancistrocladaceae) in Africa, with a New Species from Western Cameroon

2. Further Notes on West African Ancistrocladus

3. G.Bringmann and F.Pokorny , The naphthylisoquinoline alkaloids , in The Alkaloids , ed. G. A. Cordell , Academic Press Inc , New York , 1995 , vol. 46 , pp. 127–271

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2. Correction: Naphthylisoindolinone alkaloids: the first ring-contracted naphthylisoquinolines, from the tropical liana Ancistrocladus abbreviatus, with cytotoxic activity;RSC Advances;2022

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