Flavonoid-based inhibitors of the Phi-class glutathione transferase from black-grass to combat multiple herbicide resistance

Author:

Schwarz Maria1,Eno Rebecca F. M.1,Freitag-Pohl Stefanie1ORCID,Coxon Christopher R.1,Straker Hannah E.1,Wortley David J.2,Hughes David J.3,Mitchell Glynn3,Moore Jenny3,Cummins Ian4,Onkokesung Nawaporn5ORCID,Brazier-Hicks Melissa5,Edwards Robert5,Pohl Ehmke14ORCID,Steel Patrick G.1ORCID

Affiliation:

1. Department of Chemistry, University of Durham, Science Laboratories, South Road, Durham, DH1 3LE, UK

2. Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, UK

3. Syngenta, Jealott's Hill International Research Station, Bracknell, Berks RG42 6EY, UK

4. Department of Biosciences, University of Durham, Science Laboratories, South Road, Durham, DH1 3LE, UK

5. Agriculture, School of Natural and Environmental Sciences, Newcastle University, Newcastle-upon-Tyne, NE1 7RU, UK

Abstract

Nature inspired flavonoid derivatives bind to AmGSTF1 and overcome herbicide resistance in multiple herbicide resistant (MHR) Black Grass.

Funder

Biotechnology and Biological Sciences Research Council

Agricultural and Horticultural Development Board

Syngenta International

Daphne Jackson Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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