Intervertebral disc organ-on-a-chip: an innovative model to study monocyte extravasation during nucleus pulposus degeneration-Reference-Cited by-同舟云学术

Intervertebral disc organ-on-a-chip: an innovative model to study monocyte extravasation during nucleus pulposus degeneration

Published:2023 Issue:12 Volume:23 Page:2819-2828
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Son Hyeong-Guk¹^ORCID,Hwang Min-Ho¹^ORCID,Lee Sumin²³^ORCID,Kim An-Gi¹^ORCID,Kim Tae-Won¹^ORCID,Kim Joo-Han⁴^ORCID,Choi Hyuk¹^ORCID,Jeong Sehoon²³^ORCID

Affiliation:

1. Department of Medical Sciences, Graduate School of Medicine, Korea University, 80, Guro-dong, Guro-gu, Seoul 152703, South Korea

2. Department of Healthcare Information Technology, Inje University, 197 Inje-Ro, Gimhae 50834, South Korea

3. Institute for Digital Antiaging and Healthcare, Inje University, Gimhae 50834, Republic of Korea

4. Department of Neurosurgery, Guro Hospital, College of Medicine, Korea University, 80, Guro-dong, Guro-gu, Seoul 152-703, South Korea

Abstract

The intervertebral disc (IVD) organ-on-a-chip is a multi-cellular analytical platform that recapitulates the geometry of the IVD. This bioinspired microsystem mimics monocyte extravasation and enables the study of cell-to-cell paracrine signaling by utilizing chemotaxis.

Funder

National Research Foundation of Korea

Korea University Guro Hospital

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/LC/D3LC00032J

Reference26 articles.

1. Role of cytokines in intervertebral disc degeneration: pain and disc content

2. Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions

3. Genetic Therapy for Intervertebral Disc Degeneration

4. MMPs and ADAMTSs in intervertebral disc degeneration

5. The involvement of immune system in intervertebral disc herniation and degeneration

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