A glutathione disulfide-sensitive Janus nanomachine controlled by an enzymatic AND logic gate for smart delivery-Reference-Cited by-同舟云学术

A glutathione disulfide-sensitive Janus nanomachine controlled by an enzymatic AND logic gate for smart delivery

Published:2021 Issue:44 Volume:13 Page:18616-18625
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Mayol Beatriz¹^ORCID,Díez Paula¹,Sánchez Alfredo¹,de la Torre Cristina²³⁴,Villalonga Anabel¹,Lucena-Sánchez Elena²³⁴,Sancenón Félix²³⁴,Martínez-Ruiz Paloma¹^ORCID,Vilela Diana¹,Martínez-Máñez Ramón²³⁴⁵^ORCID,Villalonga Reynaldo¹^ORCID

Affiliation:

1. Nanosensors and Nanomachines Group, Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, 28040 Madrid, Spain

2. Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, Camino de Vera s/n, 46022, Valencia, Spain

3. Unidad Mixta UPV-CIPF de Investigación en Mecanismos de Enfermedades y Nanomedicina, Universitat Politècnica de València, Centro de Investigación Príncipe Felipe, Valencia, Spain

4. CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain

5. Unidad Mixta de Investigación en Nanomedicina y Sensores. Universitat Politècnica de València, Instituto de Investigación Sanitaria La Fe, Valencia, Spain

Abstract

A new enzyme-controlled Janus nanomachine operated through an AND Boolean logic gate was assembled on Janus Au-mesoporous silica nanoparticles capped with thiol-sensitive molecular gates and functionalized with glutathione reductase.

Funder

Generalitat Valenciana

Secretaría de Estado de Investigación, Desarrollo e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NR/D0NR08282A

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