Late-stage diversification of biologically active pyridazinones via a direct C–H functionalization strategy

Author:

Li Wei1234,Fan Zhoulong56789,Geng Kaijun56789,Xu Youjun1234,Zhang Ao56789

Affiliation:

1. School of Pharmaceutical Engineering

2. Shenyang Pharmaceutical University

3. Shenyang 110016

4. China

5. CAS Key Laboratory of Receptor Research

6. and Synthetic Organic & Medicinal Chemistry Laboratory (SOMCL)

7. Shanghai Institute of Materia Medica (SIMM)

8. Chinese Academy of Sciences

9. Shanghai 201203

Abstract

Divergent ortho-selective C–H functionalization was successfully established using a pyridazinone moiety as an internal directing group.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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