Stereoselective synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc) and ureido-DNJNAc derivatives as new hexosaminidase inhibitors-Reference-Cited by-同舟云学术

Stereoselective synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc) and ureido-DNJNAc derivatives as new hexosaminidase inhibitors

Published:2015 Issue:23 Volume:13 Page:6500-6510
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

de la Fuente Alex¹²³,Mena-Barragán Teresa⁴⁵⁶⁷³,Farrar-Tobar Ronald A.¹²³,Verdaguer Xavier¹²³⁸⁹,García Fernández José M.¹⁰¹¹¹²³,Ortiz Mellet Carmen⁴⁵⁶⁷³,Riera Antoni¹²³⁸⁹

Affiliation:

1. Institute for Research in Biomedicine (IRB Barcelona)

2. E-08028 Barcelona

3. Spain

4. Departamento de Química Orgánica

5. Facultad de Química

6. Universidad de Sevilla

7. E-41012 Sevilla

8. Departament de Química Orgànica

9. Universitat de Barcelona

10. Instituto de Investigaciones Químicas (IIQ)

11. CSIC – Universidad de Sevilla

12. E-41092 Sevilla

Abstract

A novel approach to the synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc) and ureido-DNJNAc derivatives as potent hexosaminidase inhibitors is reported.

Funder

Consejería Economía, Innovación, Ciencia y Empleo, Junta de Andalucia

Ministerio de Economía y Competitividad

Institute for Research in Biomedicine

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00507H

Reference71 articles.

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