Sulfonate improves water solubility and cell selective toxicity and alters the lysozyme binding activity of half sandwich Rh(iii) complexes

Author:

Mansour Ahmed M.12345ORCID,Radacki Krzysztof6789ORCID,Shehab Ola R.12345ORCID

Affiliation:

1. Department of Chemistry

2. Faculty of Science

3. Cairo University

4. Giza

5. Egypt

6. Institut für Anorganische Chemie

7. Julius-Maximilians-Universität Würzburg

8. D-97074 Würzburg

9. Germany

Abstract

Introduction of the propyl-sulfonic acid group at N1 of the coordinated 2(pyridyl)benzimidazole ligand (L) in [RhCl(η5-C5Me5)L](CF3SO3) gives rise to a water-soluble complex, which shows comparable antifungal activity to Fluconazole.

Funder

Wellcome Trust

University of Queensland

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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