Hydrogen-bonded supramolecular micelle-mediated drug delivery enhances the efficacy and safety of cancer chemotherapy

Author:

Cheng Chih-Chia12345ORCID,Sun Ya-Ting1234,Lee Ai-Wei678910,Huang Shan-You1234,Fan Wen-Lu1234,Chiao Yu-Hsuan11121314,Chiu Chih-Wei15234,Lai Juin-Yih12345

Affiliation:

1. Graduate Institute of Applied Science and Technology

2. National Taiwan University of Science and Technology

3. Taipei 10607

4. Taiwan

5. Advanced Membrane Materials Research Center

6. Department of Anatomy and Cell Biology

7. School of Medicine

8. College of Medicine

9. Taipei Medical University

10. Taipei

11. Department of Chemical Engineering

12. University of Arkansas

13. Fayetteville

14. USA

15. Department of Materials Science and Engineering

Abstract

Multiple hydrogen-bonded supramolecular polymers tend to form stable spherical micelles with oppositely charged anticancer drugs in biological environments, which improves cellular drug uptake and more effectively induces apoptosis in cancer cells.

Funder

Ministry of Science and Technology, Taiwan

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

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