Phosphinate esters as novel warheads for activity-based probes targeting serine proteases-Reference-Cited by-同舟云学术

Phosphinate esters as novel warheads for activity-based probes targeting serine proteases

Published:2021 Issue:4 Volume:2 Page:1285-1290
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Kahler Jan Pascal¹²³⁴⁵^ORCID,Verhelst Steven H. L.¹²³⁴⁵^ORCID

Affiliation:

1. Laboratory of Chemical Biology

2. Department of Cellular and Molecular Medicine

3. KU Leuven

4. 3000 Leuven

5. Belgium

Abstract

Phosphinate electrophiles are developed as activity-based probes for serine proteases. They can be used for gel-based profiling as well as for microscopy-based detection, and their use is here demonstrated on neutrophil serine proteases.

Funder

Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen

Fonds Wetenschappelijk Onderzoek

Herculesstichting

Bundesministerium für Bildung und Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CB/D1CB00117E

Reference34 articles.

1. Activity-Based Profiling of Proteases

2. Activity-Based Probes for the Study of Proteases: Recent Advances and Developments

3. Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response

4. Targeting matrix metalloproteinases in cancer: Bringing new life to old ideas

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