Improving the catalytic efficiency and stereoselectivity of a nitrilase from Synechocystis sp. PCC6803 by semi-rational engineering en route to chiral γ-amino acids-Reference-Cited by-同舟云学术

Improving the catalytic efficiency and stereoselectivity of a nitrilase from Synechocystis sp. PCC6803 by semi-rational engineering en route to chiral γ-amino acids

Published:2019 Issue:6 Volume:9 Page:1504-1510
ISSN:2044-4753
Container-title:Catalysis Science & Technology
language:en
Short-container-title:Catal. Sci. Technol.

Author:

Yu Shanshan¹²³⁴⁵^ORCID,Yao Peiyuan¹²³⁴⁵^ORCID,Li Jinlong¹²³⁴⁵^ORCID,Feng Jinhui¹²³⁴⁵^ORCID,Wu Qiaqing¹²³⁴⁵^ORCID,Zhu Dunming¹²³⁴⁵^ORCID

Affiliation:

1. National Engineering Laboratory for Industrial Enzymes

2. Tianjin Engineering Research Center of Biocatalytic Technology

3. Tianjin Institute of Industrial Biotechnology

4. Chinese Academy of Sciences

5. Tianjin 300308

Abstract

Simultaneously improving activity and stereoselectivity of a nitrilase to catalyze the desymmetrization of 3-substituted glutaronitriles is presented.

Funder

National Natural Science Foundation of China

Chinese Academy of Sciences

Tianjin Science and Technology Committee

Publisher

Royal Society of Chemistry (RSC)

Subject

Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CY/C8CY02455C

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1. Asymmetric Synthetic Strategies of (R)-(–)-Baclofen: An Antispastic Drug