Zeolitic imidazolate framework-90 loaded with methylprednisolone sodium succinate effectively reduces hypertrophic scar in vivo

Author:

Xu Xiaoxiang1,Liu Jun12,Xiao Zixuan3,Li Shuang1,Zhang Ya1,Song Peng1,Lin Kun1,Zhang Lei3,Zheng Haoquan4ORCID,Zhou Yuye56ORCID,Chen Xiong1

Affiliation:

1. Department of Otorhinolaryngology-Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China

2. Department of Otorhinolaryngology-Head and Neck Surgery, Yichang Central People's Hospital, The First College of Clinical Medical Science, China Three Gorges University, Yichang 430003, China

3. National Engineering Laboratory for Resource Developing of Endangered Chinese Crude Drugs in Northwest of China, China-Sweden International Joint Research Center for Brain Diseases, College of Life Sciences, Shaanxi Normal University, Xi'an, 710119, China

4. Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710119, China

5. School of Engineering Sciences in Chemistry, Biotechnology and Health, Department of Chemistry, Division of Applied Physical Chemistry, Analytical Chemistry, KTH Royal Institute of Technology, SE-10044 Stockholm, Sweden

6. Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH), CH-8093 Zürich, Switzerland

Abstract

Hypertrophic scar (HS) is characterized by an abnormal fibroblast-myofibroblast transformation; non-apoptosis of fibroblasts; and redundant expression of TGF-β1, VEGF, α-SMA, and collagen I/III.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Vetenskapsrådet

Publisher

Royal Society of Chemistry (RSC)

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