Getting a lead on Pb2+-amide chelators for 203/212Pb radiopharmaceuticals

Author:

Ingham Aidan12ORCID,Kostelnik Thomas I.12ORCID,McNeil Brooke L.23ORCID,Patrick Brian O.4ORCID,Choudhary Neha12ORCID,Jaraquemada-Peláez María de Guadalupe1ORCID,Orvig Chris1ORCID

Affiliation:

1. Medicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia, V6 T 1Z1, Canada

2. Life Sciences Division, TRIUMF, 4004 Wesbrook Mall, Vancouver, British Columbia, V6 T 2A3, Canada

3. Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, V5A 1S6, Canada

4. Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia, V6 T 1Z1, Canada

Abstract

Three chelators were developed for potential use in 203/212Pb-based radiopharmaceuticals. Studies probing the coordination chemistry of the metal complexes and radiolabeling capabilities revealed a compound for future study.

Funder

University of British Columbia

Canadian Institutes of Health Research

Mitacs

Natural Sciences and Engineering Research Council of Canada

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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