Coupled molecular design diagrams to guide safer chemical design with reduced likelihood of perturbing the NRF2-ARE antioxidant pathway and inducing cytotoxicity-Reference-Cited by-同舟云学术

Coupled molecular design diagrams to guide safer chemical design with reduced likelihood of perturbing the NRF2-ARE antioxidant pathway and inducing cytotoxicity

Published:2016 Issue:23 Volume:18 Page:6387-6394
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Shen Longzhu Q.¹²³,Melnikov Fjodor¹²³,Roethle John⁴⁵²³,Gudibanda Aditya⁶⁵²³,Judson Richard S.⁷⁸³,Zimmerman Julie B.¹²³⁹⁵,Anastas Paul T.¹²³⁴⁵

Affiliation:

1. School of Forestry and Environmental Studies

2. New Haven

3. USA

4. Department of Chemistry

5. Yale University

6. Department of Computer Science

7. U.S. EPA

8. National Center for Computational Toxicology

9. Department of Chemical and Environmental Engineering

Abstract

A probabilistic diagram presenting the complete solution in the variable space to guide safer chemical against NRF2-ARE pathway perturbation.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/GC/C6GC02073A

Reference77 articles.

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3. The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic

4. Molecular Mechanisms Activating the Nrf2-Keap1 Pathway of Antioxidant Gene Regulation

5. Role of Nrf2 in Oxidative Stress and Toxicity

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