Design, synthesis and biological evaluation of 5′-C-piperidinyl-5′-O-aminoribosyluridines as potential antibacterial agents-Reference-Cited by-同舟云学术

Design, synthesis and biological evaluation of 5′-C-piperidinyl-5′-O-aminoribosyluridines as potential antibacterial agents

Published:2015 Issue:28 Volume:13 Page:7720-7735
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Nakaya Takeshi¹²³⁴,Matsuda Akira¹²³⁴⁵,Ichikawa Satoshi¹²³⁴⁵

Affiliation:

1. Faculty of Pharmaceutical Sciences

2. Hokkaido University

3. Sapporo 060-0812

4. Japan

5. Center for Research and Education on Drug Discovery

Abstract

Caprazamycin analogues, which were designed and synthesized via an aza-Prins–Ritter reaction, exhibit a good MraY and antibacterial activity without cytotoxicity against human cells.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB01037C

Reference41 articles.

1. Challenges in Antimicrobial Drug Discovery and the Potential of Nucleoside Antibiotics

2. Oxazolidinone Structure–Activity Relationships Leading to Linezolid

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4. Fidaxomicin: A Review of Its Use in Patients with Clostridium difficile Infection

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