A non-zipper-like tetrameric coiled coil promotes membrane fusion-Reference-Cited by-同舟云学术

A non-zipper-like tetrameric coiled coil promotes membrane fusion

Published:2016 Issue:10 Volume:6 Page:7990-7998
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zheng Tingting¹²³⁴⁵,Bulacu Monica⁶⁴⁵,Daudey Geert¹²³⁴⁵,Versluis Frank¹²³⁴⁵,Voskuhl Jens¹²³⁴⁵,Martelli Giuliana¹²³⁴⁵,Raap Jan¹²³⁴⁵,Sevink G. J. Agur⁷²³⁴⁵,Kros Alexander¹²³⁴⁵^ORCID,Boyle Aimee L.¹²³⁴⁵

Affiliation:

1. Supramolecular and Biomaterials Chemistry

2. Leiden Institute of Chemistry

3. Leiden University

4. Leiden

5. The Netherlands

6. Culgi BV

7. Solid State NMR

Abstract

A parallel heterodimeric coiled coil can be mutated to an antiparallel tetrameric species by reversing the sequences of one of the peptides. This tetramer is capable of facilitating fast, efficient, membrane fusion of liposomes.

Funder

European Research Council

Stichting voor Fundamenteel Onderzoek der Materie

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA26175A

Reference51 articles.

1. SNAREs and SNARE regulators in membrane fusion and exocytosis