Binding mechanism of uranyl to transferrin implicated by density functional theory study

Author:

Wang Meng12345ORCID,Ding Wanjian12345,Wang Dongqi678910

Affiliation:

1. Key Laboratory of Theoretical and Computational Photochemistry

2. Ministry of Education

3. College of Chemistry

4. Beijing Normal University

5. Beijing 100875

6. CAS Key Laboratory of Nuclear Radiation and Nuclear Energy Techniques

7. Institute of High Energy Physics

8. Chinese Academy of Sciences

9. Beijing 100049

10. China

Abstract

The binding of uranyl to serum transferrin follows a Tyr* → Tyr* → Asp* stepwise mechanism.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference45 articles.

1. J. Grenthe , J.Drożdżyński, T.Fujino, E. C.Buck, T. E.Albrecht-Schmitt and S. F.Wolf, in The Chemistry of The Actinide and Transactinide Elements, ed. L. R. Morss, N. M. Edelstein, J. Fuger and J. J. Katz, Springer, Dordrecht, The Netherlands, 2006

2. Formation of Clustered DNA Damage after High-LET Irradiation: A Review

3. Uranyl Nitrilotriacetate, a Stabilized Salt of Uranium, is Genotoxic in Nontransformed Human Colon Cells and in the Human Colon Adenoma Cell Line LT97

4. Particulate Depleted Uranium Is Cytotoxic and Clastogenic to Human Lung Cells

5. The brain is a target organ after acute exposure to depleted uranium

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