Inhibition of thioredoxin reductase and upregulation of apoptosis genes for effective anti-tumor sono-chemotherapy using a meso-organosilica nanomedicine

Author:

Li Mengwen12,Tian Yue1,Wen Xiaoming12,Fu Jingke3ORCID,Gao Jianyong4,Zhu Yingchun12ORCID

Affiliation:

1. Key Laboratory of Inorganic Coating Materials CAS, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China

2. Center of Materials Science and Optoelectronics Engineer, University of Chinese Academy of Sciences, Beijing 100049, China

3. Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; Shanghai Engineering Research Center of Innovative Orthopaedic Instruments and Personalized Medicine, Shanghai 200011, PR China

4. Department of Stomatology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai 200433, China

Abstract

Chemotherapy in combination with sonodynamic therapy is performed with CQ@MOS, leading to TrxR inhibition, severe ROS accumulation, pro-apoptotic gene upregulation in the JNK pathway, autophagy inhibition and tumor apoptosis.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

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