Sulfated poly-amido-saccharides (sulPASs) are anticoagulants in vitro and in vivo-Reference-Cited by-同舟云学术

Sulfated poly-amido-saccharides (sulPASs) are anticoagulants in vitro and in vivo

Published:2021 Issue:38 Volume:12 Page:12719-12725
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Varghese Maria¹^ORCID,Rokosh Rae S.²^ORCID,Haller Carolyn A.²^ORCID,Chin Stacy L.¹,Chen Jiaxuan²^ORCID,Dai Erbin²,Xiao Ruiqing¹^ORCID,Chaikof Elliot L.²^ORCID,Grinstaff Mark W.¹^ORCID

Affiliation:

1. Departments of Chemistry, Biomedical Engineering, and Medicine, Boston University, Boston, MA 02215, USA

2. Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Wyss Institute of Biologically Inspired Engineering of Harvard University, Boston, MA, USA

Abstract

Heparin mimicking sulfated poly-amido-saccharides (sulPASs) are anticoagulants resistant to heparanases and reversed by protamine sulfate. In an in vivo murine model, sulPASs extend clotting time without the increased risk of bleeding.

Funder

National Institutes of Health

Boston University

Uniformed Services University of the Health Sciences

Beth Israel Deaconess Medical Center

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC02302K

Reference58 articles.