Selective degradation-inducing probes for studying cereblon (CRBN) biology-Reference-Cited by-同舟云学术

Selective degradation-inducing probes for studying cereblon (CRBN) biology

Published:2021 Issue:8 Volume:12 Page:1381-1390
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Powell Chelsea E.¹²^ORCID,Du Guangyan¹²,Bushman Jonathan W.¹²,He Zhixiang¹²,Zhang Tinghu¹²,Fischer Eric S.¹²,Gray Nathanael S.¹²^ORCID

Affiliation:

1. Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA

2. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA

Abstract

Thorough compound characterization by combination western and proteomic analysis identified ZXH-4-130 and ZXH-4-137 as potent and selective small molecule degraders of cereblon (CRBN).

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D0MD00382D

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