Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection-Reference-Cited by-同舟云学术

Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection

Published:2024 Issue:4 Volume:15 Page:1176-1188
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Jalencas Xavier¹^ORCID,Berg Hannes²³^ORCID,Espeland Ludvik Olai⁴⁵^ORCID,Sreeramulu Sridhar²³^ORCID,Kinnen Franziska²³,Richter Christian²³^ORCID,Georgiou Charis⁴^ORCID,Yadrykhinsky Vladyslav⁴^ORCID,Specker Edgar⁶,Jaudzems Kristaps⁷^ORCID,Miletić Tanja⁶^ORCID,Harmel Robert⁶^ORCID,Gribbon Phil⁸⁹^ORCID,Schwalbe Harald²³¹⁰^ORCID,Brenk Ruth⁴¹¹^ORCID,Jirgensons Aigars⁷^ORCID,Zaliani Andrea⁸⁹^ORCID,Mestres Jordi¹¹²^ORCID

Affiliation:

1. Research Group on Systems Pharmacology, Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Medical Research Institute, Parc de Recerca Biomèdica (PRBB), Doctor Aiguader 88, 08003 Barcelona, Spain

2. Center for Biomolecular Magnetic Resonance (BMRZ), Institute for Organic Chemistry, Max-von-Laue-Str. 7, 60438 Frankfurt/M, Germany

3. Chemical Biology, Goethe University, Max-von-Laue-Str. 7, 60438 Frankfurt/M, Germany

4. Department of Biomedicine, University of Bergen, Jonas Lies Vei 91, 5020 Bergen, Norway

5. Department of Chemistry, University of Bergen, Allégaten 41, 5007 Bergen, Norway

6. EU-OPENSCREEN ERIC, Robert-Rössle Straße 10, 13125 Berlin, Germany

7. Latvian Institute of Organic Synthesis, Aizkraules 21, Riga LV-1006, Latvia

8. Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Schnackenburgallee 114, 22525 Hamburg, Germany

9. Fraunhofer Cluster of Excellence for Immune-Mediated Diseases (CIMD), Theodor Stern Kai 7, 60590 Frankfurt, Germany

10. Instruct-ERIC, Oxford House, Parkway Court, John Smith Drive, Oxford OX4 2JY, UK

11. Computational Biology Unit, University of Bergen, Thormøhlensgate 55, 5008 Bergen, Norway

12. Institut de Quimica Computacional i Catalisi, Facultat de Ciencies, Universitat de Girona, Maria Aurelia Capmany 69, 17003 Girona, Catalonia, Spain

Abstract

The process by which researchers from all over the world can apply for projects using the EFSL poised to the ECBL at the EU-OPENSCREEN screening facilities and optimize the hits identified through our network of chemistry partners.

Funder

European Regional Development Fund

Norges Forskningsråd

Helse Vest

Ministerio de Ciencia, Innovación y Universidades

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00724C

Reference45 articles.

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2. Twenty years on: the impact of fragments on drug discovery

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4. Library Design Strategies To Accelerate Fragment‐Based Drug Discovery

5. Fragment-to-Lead Medicinal Chemistry Publications in 2019