Garlic essential oil ameliorates depression-like behaviors in unpredictable chronic mild stress by modulating the brain NLRP3 inflammasome pathway and influencing the gut barrier and microbiota

Author:

Huang Yun-Ju1,Tsai Min-Shiuan2,Panyod Suraphan2ORCID,Liu Po-Yu3ORCID,Lu Kuan-Hung45,Weng Cheng-Yu6ORCID,Huang Huai-Syuan2,Hsu Cheng-Chih6ORCID,Sheen Lee-Yan278ORCID

Affiliation:

1. Department of Biotechnology and Food Technology, Southern Taiwan University of Science and Technology, Tainan 710301, Taiwan

2. Institute of Food Science and Technology, College of Bioresources and Agriculture, National Taiwan University, Taipei 106319, Taiwan

3. School of Medicine, College of Medcine, National Sun Yat-sen University, Kaohsiung 804201, Taiwan

4. Institute of Food Safety and Health, National Taiwan University, Taipei 100025, Taiwan

5. Institute of Environmental and Occupational Health Sciences, National Taiwan University, Taipei 100025, Taiwan

6. Department of Chemistry, National Taiwan University, Taipei 106216, Taiwan

7. Center for Food and Biomolecules, National Taiwan University, Taipei 106216, Taiwan

8. National Center for Food Safety Education and Research, National Taiwan University, Taipei 106216, Taiwan

Abstract

Garlic essential oil ameliorates the UCMS-induced depressive-like behavior by blockading the NLRP3 inflammasome and altering the gut microbiota.

Funder

Ministry of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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