Reversible stapling of unprotected peptides via chemoselective methionine bis-alkylation/dealkylation-Reference-Cited by-同舟云学术

Reversible stapling of unprotected peptides via chemoselective methionine bis-alkylation/dealkylation

Published:2018 Issue:12 Volume:9 Page:3227-3232
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Shi Xiaodong¹²³⁴⁵,Zhao Rongtong¹²³⁴⁵,Jiang Yixiang¹²³⁴⁵,Zhao Hui⁶⁷⁸⁵,Tian Yuan⁹¹⁰¹¹⁵,Jiang Yanhong¹²³⁴⁵,Li Jingxu¹²³⁴⁵^ORCID,Qin Weirong¹²³⁴⁵,Yin Feng¹²³⁴⁵,Li Zigang¹²³⁴⁵

Affiliation:

1. Key Laboratory of Chemical Genomics

2. School of Chemical Biology and Biotechnology

3. Peking University Shenzhen Graduate School

4. Shenzhen

5. China

6. Division of Life Sciences

7. Clarivate Analytics

8. Beijing

9. School of Life Science and Engineering

10. Southwest Jiaotong University

11. Chengdu

Abstract

A general peptide reversible macrocyclization strategy is developed based on a facile and chemoselective methionine bis-alkylation/dealkylation process.

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/SC/C7SC05109C

Reference70 articles.

1. Modulators of Protein–Protein Interactions

2. Peptide therapeutics: current status and future directions