Probing juxtaposed G-quadruplex and hairpin motifs using a responsive nucleoside probe: a unique scaffold for chemotherapy-Reference-Cited by-同舟云学术

Probing juxtaposed G-quadruplex and hairpin motifs using a responsive nucleoside probe: a unique scaffold for chemotherapy

Published:2023 Issue:21 Volume:14 Page:5627-5637
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Khatik Saddam Y.¹^ORCID,Sudhakar Sruthi²^ORCID,Mishra Satyajit³^ORCID,Kalia Jeet³⁴^ORCID,Pradeepkumar P. I.²^ORCID,Srivatsan Seergazhi G.¹^ORCID

Affiliation:

1. Department of Chemistry, Indian Institute of Science Education and Research (IISER), Pune, Dr Homi Bhabha Road, Pune 411008, India

2. Department of Chemistry, Indian Institute of Technology Bombay, Mumbai 400076, India

3. Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal Bypass Road, Bhauri, Bhopal 462066, India

4. Department of Chemistry, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal Bypass Road, Bhauri, Bhopal 462066, India

Abstract

We report the use of a new dual-app nucleoside probe composed of environment-sensitive fluorescent and19F NMR labels in dissecting the structural polymorphism of G-quadruplexes formed by the EGFR gene, which is implicated in many cancers.

Funder

Science and Engineering Research Board

The Wellcome Trust DBT India Alliance

Indian Institute of Science Education and Research Pune

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC00519D

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1. Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells