Conformation–activity relationships of polyketide natural products-Reference-Cited by-同舟云学术

Conformation–activity relationships of polyketide natural products

Published:2015 Issue:8 Volume:32 Page:1183-1206
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Larsen Erik M.¹²³⁴,Wilson Matthew R.¹²³⁴,Taylor Richard E.¹²³⁴

Affiliation:

1. University of Notre Dame

2. Department of Chemistry & Biochemistry

3. Notre Dame

4. USA

Abstract

This review provides a comprehensive look into investigations that probe the conformational properties of polyketide natural products in order to exploit them in the design of bioactive analogues.

Funder

National Institutes of Health

Division of Chemistry

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/NP/C5NP00014A

Reference207 articles.

1. Molecular Properties That Influence the Oral Bioavailability of Drug Candidates

2. Flexible Molecules with Defined Shape?Conformational Design

3. Entropy-Enthalpy Compensation: Role and Ramifications in Biomolecular Ligand Recognition and Design

4. Function-Oriented Synthesis, Step Economy, and Drug Design

5. For information on the bryostatins in clinical trials, see: http://clinicaltrials.gov

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