Epimerization-free access to C-terminal cysteine peptide acids, carboxamides, secondary amides, and esters via complimentary strategies
Author:
Affiliation:
1. Wayne State University
2. Department of Chemistry
3. Detroit
4. USA 48202
Abstract
We present a convenient method for the diversification of peptides bearing cysteine at the C-terminus that proceeds to form a variety of carboxylic acid, carboxamide, 2° amide, and ester terminated peptides without any detectable epimerization of the α-stereocenter.
Funder
Division of Chemistry
National Institute of General Medical Sciences
Wayne State University
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/SC/C7SC03553E
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