Discovery of new pyridine heterocyclic hybrids; design, synthesis, dynamic simulations, and <i>in vitro</i> and <i>in vivo</i> breast cancer biological assays-Reference-Cited by-同舟云学术

Discovery of new pyridine heterocyclic hybrids; design, synthesis, dynamic simulations, and in vitro and in vivo breast cancer biological assays

Published:2023 Issue:23 Volume:13 Page:15689-15703
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Abdelshaheed Menna M.¹,El Subbagh Hussein I.²,Tantawy Mohamed A.³⁴⁵,Attia Reem T.⁶,Youssef Khairia M.⁷,Fawzy Iten M.⁷^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University in Egypt, New Damietta, Egypt

2. Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, P.O. Box 35516, Mansoura, Egypt

3. Hormones Department, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, Giza, Egypt

4. Stem Cells Lab, Center of Excellence for Advanced Sciences, National Research Centre, Dokki, Cairo, Egypt

5. Department of Orthopaedics and Rehabilitation, CORTS, Penn State University, College of Medicine, 500 University Drive, Hershey, PA 17033-0850, USA

6. Department of Pharmacology and Toxicology and Biochemistry, Faculty of Pharmacy, Future University in Egypt, 11835, Cairo, Egypt

7. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Future University in Egypt, 11835, Cairo, Egypt

Abstract

Compound 3b was designed and synthesized as pyrano-pyridine hybrid that showed high potency in the in vitro antiproliferative assay, 81% inhibition to polymerization of tubulin, high dynamic stability and 79% reduction in tumor size of breast cancer in vivo assay.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA02875E

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