Ligand compatibility of salacinol-type α-glucosidase inhibitors toward the GH31 family-Reference-Cited by-同舟云学术

Ligand compatibility of salacinol-type α-glucosidase inhibitors toward the GH31 family

Published:2021 Issue:6 Volume:11 Page:3221-3225
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Ishikawa Fumihiro¹²³⁴⁵^ORCID,Hirano Aiko¹²³⁴⁵,Yoshimori Yuuto¹²³⁴⁵,Nishida Kana¹²³⁴⁵,Nakamura Shinya⁶²³⁴⁵,Takashima Katsuki¹²³⁴⁵,Marumoto Shinsuke⁷³⁴⁵,Ninomiya Kiyofumi⁸³⁴⁵,Nakanishi Isao⁶²³⁴⁵,Xie Weijia⁹¹⁰¹¹¹²¹³,Morikawa Toshio⁸³⁴⁵^ORCID,Muraoka Osamu⁸³⁴⁵,Tanabe Genzoh¹²³⁴⁵^ORCID

Affiliation:

1. Pharmaceutical Organic Chemistry Lab

2. Faculty of Pharmacy

3. Kindai University

4. Higashi-Osaka

5. Japan

6. Computational Drug Design and Discovery Lab

7. Joint Research Center

8. Pharmaceutical Research and Technology Institute

9. State Key Laboratory of Natural Medicines

10. Department of Medicinal Chemistry

11. China Pharmaceutical University

12. Nanjing 2100009

13. P. R. China

Abstract

Salacinol-type α-glucosidase inhibitors are ligand-compatible with the GH 31 family. Salacinol and its 3′-O-benzylated analogs inhibit human lysosomal α-glucosidase at submicromolar levels.

Funder

Japan Society for the Promotion of Science

Noda Institute for Scientific Research

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D0RA10038B

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4. Pharmacological Treatment of Obesity: Therapeutic Strategies

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