Sulforaphane protects microvascular endothelial cells in lower limb ischemia/reperfusion injury mice-Reference-Cited by-同舟云学术

Sulforaphane protects microvascular endothelial cells in lower limb ischemia/reperfusion injury mice

Published:2023 Issue:15 Volume:14 Page:7176-7194
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Chen Fanfeng¹²³,Zhan Jiayu³,Al Mamun Abdullah³,Tao Yibing³,Huang Shanshan³,Zhao Jiaxin³,Zhang Yu³,Xu Yitie³,Du Shenghu¹²³,Lu Wei²,Li Xiaokun¹²³,Chen Zimiao¹,Xiao Jian¹²³^ORCID

Affiliation:

1. Department of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China

2. The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China

3. Molecular Pharmacology Research Center, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou 325000, China

Abstract

Mechanism by which SFN improving microvascular damage in limbs insulted by I/R injury. SFN activates TFEB via MCOLN1-calcineurin signaling. SFN-induced TFEB activation augments autophagy restoration, anti-oxidant response and anti-apoptosis effect.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D3FO01801F

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