Unlike RNA-TBA (rTBA), iso-rTBA, the 2′–5′-linked RNA-thrombin-binding aptamer, is a functional equivalent of TBA-Reference-Cited by-同舟云学术

Unlike RNA-TBA (rTBA), iso-rTBA, the 2′–5′-linked RNA-thrombin-binding aptamer, is a functional equivalent of TBA

Published:2023 Issue:11 Volume:59 Page:1461-1464
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Wagh Atish A.¹²,Kumar Vaijayanti A.¹²,Ravindranathan Sapna²³,Fernandes Moneesha¹²^ORCID

Affiliation:

1. Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Pune 411008, India

2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India

3. Central NMR Facility, CSIR-National Chemical Laboratory (CSIR-NCL), Pune 411008, India

Abstract

2′–5′-Linked RNA thrombin-binding aptamer (iso-rTBA) folds into a stable antiparallel G-quadruplex that can efficiently inhibit clotting and resist nuclease degradation.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CC/D2CC05718B

Reference24 articles.

1. Selection of single-stranded DNA molecules that bind and inhibit human thrombin

2. G-Quadruplex-Forming Aptamers—Characteristics, Applications, and Perspectives

3. A Mini-Review: Clinical Development and Potential of Aptamers for Thrombotic Events Treatment and Monitoring

4. Antithrombotic therapy in patients with COVID-19? -Rationale and Evidence-

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1. Improving the Biological Properties of Thrombin-Binding Aptamer by Incorporation of 8-Bromo-2′-Deoxyguanosine and 2′-Substituted RNA Analogues;International Journal of Molecular Sciences;2023-10-24