The molecular basis of the interactions between synthetic retinoic acid analogues and the retinoic acid receptors-Reference-Cited by-同舟云学术

The molecular basis of the interactions between synthetic retinoic acid analogues and the retinoic acid receptors

Published:2017 Issue:3 Volume:8 Page:578-592
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Haffez Hesham¹²³⁴⁵^ORCID,Chisholm David R.¹²³,Valentine Roy⁶⁷²³,Pohl Ehmke⁴⁵⁸³,Redfern Christopher⁹¹⁰¹¹¹²³^ORCID,Whiting Andrew¹²³^ORCID

Affiliation:

1. Department of Chemistry Durham University

2. Durham

3. UK

4. Department of Biosciences & Biophysical Sciences

5. Institute Durham University

6. High Force Research Ltd.

7. Bowburn North Industrial Estate

8. Durham DH1 3LE

9. Northern Institute for Cancer Research

10. Medical School

11. Newcastle University

12. Newcastle upon Tyne

Abstract

Molecular docking and ligand binding assays shed new light on the conformational flexibility of natural retinoids compared with less flexible synthetic ligands during binding to RARs and the resulting impact upon on the design of synthetic analogues.

Funder

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C6MD00680A

Reference54 articles.

1. Retinoids regulate stem cell differentiation

2. A decade of molecular biology of retinoic acid receptors